4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE Chemical Properties

Melting point:

229-230 °C

Boiling point:

593.7±50.0 °C(Predicted)

Density 

1.507±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform: Slightly Soluble
DMSO: Soluble
Methanol: Slightly Soluble

form 

Solid

pka

6.15±0.40(Predicted)

color 

White to yellow

InChI

InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-12(23-2)10(18)5-8/h3-7,18-19,21H,1-2H3

InChIKey

BWORNNDZQGOKBY-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(OC)C(O)=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1O

4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE Usage And Synthesis

Uses

Ombuin is a synthetic flavonoid which displays activity as a potent mycobacterium tuberculosis inhibitor.

Definition

ChEBI: Ombuin is a dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4' are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent and a plant metabolite. It is a trihydroxyflavone, a member of flavonols and a dimethoxyflavone. It is functionally related to a quercetin. It is a conjugate acid of a 7,4'-O-dimethylquercetin 3-olate.

References

[1] FAZILATUN NESSA . Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves[J]. Food Chemistry, 2004, 88 2: Pages 243-252. DOI: 10.1016/j.foodchem.2004.01.041
[2] MEYYAMMAI SWAMINATHAN. Flavonoids with M1 muscarinic acetylcholine receptor binding activity.[J]. Molecules, 2014, 19 7: 8933-8948. DOI: 10.3390/molecules19078933
[3] D. T. HUONG. A New Flavone and Cytotoxic Activity of Flavonoid Constituents Isolated from Miliusa balansae (Annonaceae).[J]. ChemInform, 2005, 36 50. DOI: 10.1002/chin.200550192
[4] BIN LIU  Ping T  Caichun Deng. Ombuin ameliorates diabetic nephropathy in rats by anti-inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways[J]. Drug Development Research, 2022, 83 6: 1270-1280. DOI: 10.1002/ddr.21956

4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE(529-40-8)Related Product Information

• QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
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• CASTICIN
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• AYANIN
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• QUERCETINPENTAACETATE
• 3,3',4',5,6,7,8-heptamethoxyflavone
• 4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE
• Ombuoside
• QUERCETIN-7,4'-DIGLUCOSIDE
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• TAMARIXETIN-7-O-RUTINOSIDE
• RARECHEM BW GA 0414
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