Carboprost
Carboprost Basic information
- Product Name:
- Carboprost
- Synonyms:
-
- (5z,9-alpha,11-alpha,13e,15s)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1
- Carboprost Trometamol Impurity B (Carboprost)
- 15-methylpgf2-alpha
- 15s)-13e
- methyl-pgf2-alpha
- -oicacid
- prosta-5,13-dien-1-oicacid,9,11,15-trihydroxy-15-methyl-,(5z,9-alpha,11-alph
- prostin15m
- CAS:
- 35700-23-3
- MF:
- C21H36O5
- MW:
- 368.51
- Product Categories:
-
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 35700-23-3.mol
Carboprost Chemical Properties
- Melting point:
- 79-82°C
- Boiling point:
- 418.83°C (rough estimate)
- Density
- 1.0390 (rough estimate)
- refractive index
- 1.6120 (estimate)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- White
- CAS DataBase Reference
- 35700-23-3(CAS DataBase Reference)
Carboprost Usage And Synthesis
Description
15(S)-
Chemical Properties
Off- White Solid
Uses
Analog of prostaglandin F2α. Oxytocic.
Uses
Analog of prostaglandin F2a. Oxytocic
Definition
ChEBI: Prostaglandin F2alpha in which the hydrogen at position 15 is substituted by methyl (S configuration). It is used as an abortifacient agent that is effective in both the first and second trimesters of regnancy.
brand name
Hemabate (Pharmacia & Upjohn).
References
[1] MD S.J. CARLAN . Effect of intramuscular 15-methyl prostaglandin F2α after second-trimester delivery[J]. Obstetrics and gynecology, 1997, 89 1: Pages 5-9. DOI: 10.1016/s0029-7844(96)00433-4
[2] LINDBLOM B. Local prostaglandin F(2alpha) injection for termination of ectopic pregnancy[J]. International Journal of Gynecology & Obstetrics, 1988, 26 2: Page 335. DOI: 10.1016/0020-7292(88)90306-2
[3] P.G. ADAIKAN. Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study[J]. Prostaglandins, leukotrienes, and medicine, 1987, 27 2: Pages 161-167. DOI: 10.1016/0262-1746(87)90068-0
[4] WILKS J W. Inhibition of the monkey corpus luteum with 15-methyl prostaglandins[J]. Prostaglandins, 1980, 20 5: Pages 793-805. DOI: 10.1016/0090-6980(80)90134-3
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