(D-PEN2,PEN5)-ENKEPHALIN
(D-PEN2,PEN5)-ENKEPHALIN Basic information
- Product Name:
- (D-PEN2,PEN5)-ENKEPHALIN
- Synonyms:
-
- TYR-D-PEN-GLY-PHE-PEN
- L-Tyr-D-Pen-Glu-L-Phe-L-Pen-OH
- Tyr-D-Pen-Gly-Phe-D-Pen (Disulfide bridge D-Pen2-D-Pen5)
- (D-PEN2,PEN5)-ENKEPHALIN
- [D-PEN2,L-PEN5]-ENKEPHALIN
- DPLPE
- H-TYR-D-PEN-GLY-PHE-PEN-OH
- H-Tyr-D-Pen-Gly-Phe-Pen-OH (Disulfide bond)
- CAS:
- 88373-72-2
- MF:
- C30H39N5O7S2
- MW:
- 645.79
- Mol File:
- 88373-72-2.mol
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(D-PEN2,PEN5)-ENKEPHALIN Chemical Properties
- storage temp.
- −20°C
- form
- Solid
MSDS
- Language:English Provider:SigmaAldrich
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(D-PEN2,PEN5)-ENKEPHALIN Usage And Synthesis
Uses
[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin.html" class="link-product" target="_blank">[Leu5]-Enkephalin (HY-P0288)[1].
in vivo
[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1].
| Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] |
| Dosage: | 0, 1.16, 11.6 μg/kg |
| Administration: | IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding. |
| Result: | Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect. |
| Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] |
| Dosage: | 0, 0.332, 3.32 μg/kg |
| Administration: | IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment |
| Result: | Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect. |
IC 50
δ Opioid Receptor/DOR
References
[1] Martinez JL Jr, et al. D-Pen2-[D-Pen5]enkephalin impairs acquisition and enhances retention of a one-way active avoidance response in rats. Peptides. 1992 Sep-Oct;13(5):885-9. DOI:10.1016/0196-9781(92)90045-5
(D-PEN2,PEN5)-ENKEPHALINSupplier
GL Biochem (Shanghai) Ltd
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Shanghai Hanhong Scientific Co.,Ltd.
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Nanjing Leon Biological Technology Co., Ltd.
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- 17705183659
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(D-PEN2,PEN5)-ENKEPHALIN(88373-72-2)Related Product Information
- L-Penicillamine
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- isopropyl methyl disulphide
- sec-Butyl disulfide
- ISOPROPYL DISULFIDE
- Di-tert-butyl disulfide
- N-ACETYL-DL-PENICILLAMINE
- (D-PEN2,P-CHLORO-PHE4,D-PEN5)-ENKEPHALIN
- [DES-TYR1, D-PEN2, PEN5]-ENKEPHALIN
- DI-TERT-AMYL DISULFIDE
- (D-PEN2,PEN5)-ENKEPHALIN
- H-PHE-VAL-OH
- N-Propionyl-L-cysteine
- isopropyl propyl disulphide
- DPDPE [TYROSYL-3,6-3H(N)]-