TETRACYCLINE PHOSPHATE COMPLEX Chemical Properties

storage temp. 

−20°C

form 

powder

color 

yellow to yellow with an orange cast

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-40

Safety Statements 

22-36-45

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

TETRACYCLINE PHOSPHATE COMPLEX Usage And Synthesis

Originator

Tetrex,Bristol,US,1956

Uses

Tetracycline phosphate complex is an antibiotic useful in an array of bioassays.

Manufacturing Process

In a 500-ml round-bottomed flask equipped with stirrer, condenser and thermometer was placed 7.1 grams (0.05 mol) P2O5 which was immediately covered with 100 ml of chloroform. To the mixture was added with stirring 0.9 ml (0.05 mol) of distilled water. In a few minutes, a lower oily layer appeared, which was believed to be freshly formed metaphosphoric acid resulting from the action of the P2O5 with an equimolar amount of water. To this mixture was added 100 ml of methanol and on continued stirring, the lower oily layer disappeared in the methanol forming a complete pale yellowish-green colored solution.
An additional 50 ml of methanol was added to the flask and then 22.2 grams (0.05 mol) of tetracycline, neutral form, was added portionwise intermittently with another 50 ml of methanol. A clear solution was maintained throughout the addition of the tetracycline. After addition of all of the tetracycline, the solution was a deep orange color and the temperature in the reaction flask was 35°C.
One hour after addition of the tetracycline, the clear reaction solution was poured into 1,500 ml of chloroform. A yellow product separated and was collected on a coarse sintered glass filter and air dried. The tetracyclinemetaphosphoric acid complex weighed about 10 grams, contained 7.34% of phosphorus and had a bioassay of 634 gammas per milligram. Solubility in water is 750 mg/ml.

Therapeutic Function

Antibacterial

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