2,4,5-TRIFLUOROBENZENESULFONAMIDE Chemical Properties

Density 

1.611±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Sealed in dry,Room Temperature

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2935909099

2,4,5-TRIFLUOROBENZENESULFONAMIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2,4,5-trifluorobenzenesulfonamides from 2,4,5-trifluorobenzenesulfonyl chloride: ammonium hydroxide (NH4OH, 910 mg, 26 mmol) was slowly added to a solution of 2,4,5-trifluorobenzene-1-sulfonyl chloride (3.0 g, 13 mmol) in tetrahydrofuran (THF, 30 mL). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure to afford 2,4,5-trifluorobenzenesulfonamide (2.7 g, 13 mmol, 98% yield) as a yellow solid. The product was analyzed by electrospray ionization mass spectrometry (ESI-MS) and showed a molecular ion peak (EI+, m/z): 211.9 [M+H]+.

References

[1] Patent: WO2018/89433, 2018, A1. Location in patent: Paragraph 00411