Basic information Safety Supplier Related

TG003

Basic information Safety Supplier Related

TG003 Basic information

Product Name:
TG003
Synonyms:
  • TG003
  • (Z)-1-(3-ETHYL-5-METHOXY-2, 3-DIHYDROBENZOTHIAZOL-2-YLIDENE) PROPAN-2-ONE
  • 2-Propanone, 1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-, (1Z)-
  • (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
  • TG003(Z)
CAS:
719277-26-6
MF:
C13H15NO2S
MW:
249.33
Mol File:
Mol File
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TG003 Chemical Properties

Melting point:
132-132.5 °C
Boiling point:
386.0±42.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 33 mg/mL
form 
solid
pka
-1.54±0.20(Predicted)
color 
pale yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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TG003 Usage And Synthesis

Description

TG003 (719277-26-6) is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50‘s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3).1?Also inhibits DYRK1A/B (IC50‘s = 24 and 34 nM respectively).2 Suppresses serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles and Clk1/Sty-dependent alternative splicing in mammalian cells.1?TG003 affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Promotes skipping of exon 31 in the endogenous dystrophin gene.3 TG003 increases levels of Clk1/4 mature mRNAs by promoting splicing of the intron-retaining RNAs.4

Uses

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases.

storage

Store at +4°C

References

1) Muraki et al. (2004), Manipulation of alternative splicing by a newly developed inhibitor of Clks; J. Biol. Chem., 279 24246 2) Foucourt et al. (2014), Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II; Molecules, 19 15411 3) Nishida et al. (2011), Chemical treatment enhances skipping of a mutated exon in the dystrophin gene; Nat. Commun., 2 308 4) Ninomiya et al. (2011), Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor; J. Cell Biol., 195 27

TG003Supplier

Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
SPIRO PHARMA
Tel
Email
eric_feng1954@126.com
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TG003(719277-26-6)Related Product Information