3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Chemical Properties

Melting point:

222-224

Boiling point:

302.6±32.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.67±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2922390090

3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Usage And Synthesis

Synthesis

GENERAL METHOD: Malonic acid (1.04 g, 10 mmol) and ammonium formate (1.26 g, 20 mmol) were dissolved in ethanol (50 mL), followed by the addition of 2-fluorobenzaldehyde (10 mmol). The reaction mixture was heated to reflux for 7 hours. After completion of the reaction, it was cooled to room temperature and the crude product was collected by filtration. The crude product was purified by recrystallization (using 95% ethanol as a solvent) to give 3-amino-3-(2-fluorophenyl)propionic acid as a final white solid.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 402 - 418
[2] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 395 - 406
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 11, p. 1207 - 1212
[5] Journal of Organic Chemistry, 2009, vol. 74, # 23, p. 9152 - 9157

3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID(117391-49-8)Related Product Information

• 3-N-BOC-3-(2-FLUOROPHENYL)PROPIONIC ACID
• 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
• FMOC-(S)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• FMOC-(S)-3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
• (R)-2-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• BOC-(S)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID,(S)-3-T-BUTOXYCARBONYL-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• BOC-(R)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• (R)-2-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
• (R)-2-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID
• (S)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• FMOC-(S)-3-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID
• FMOC-(R)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• FMOC-(R)-3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
• (R)-3-T-BUTOXYCARBONYL-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID,BOC-(R)-3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
• DL-3-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID,3-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID
• 3-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID
• (S)-2-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• (R)-3-(M-FLUOROPHENYL)-BETA-ALANINE