Basic information Safety Supplier Related

(R)-N-Boc-3-pyrrolidineacetic acid

Basic information Safety Supplier Related

(R)-N-Boc-3-pyrrolidineacetic acid Basic information

Product Name:
(R)-N-Boc-3-pyrrolidineacetic acid
Synonyms:
  • (R)-1-Boc-3-pyrrolidineacetic acid
  • (R)-N-Boc-3-(R)-(1-Boc-Pyrrolidin-3-yl)-aceticacid
  • (R)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)acetic acid
  • 2-[(3R)-1-[(tert-butoxy)carbonyl]pyrrolidin-3-yl]acetic acid
  • (R)-3-CARBOXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (R)-(1-BOC-PYRROLIDIN-3-YL)-ACETIC ACID
  • (R)-N-BOC-PYRROLIDINE-3-ACETIC ACID
  • (R)-N-BOC-3-PYRROLIDINEACETIC ACID
CAS:
204688-60-8
MF:
C11H19NO4
MW:
229.27
Product Categories:
  • pharmacetical
Mol File:
204688-60-8.mol
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(R)-N-Boc-3-pyrrolidineacetic acid Chemical Properties

Boiling point:
357.4±15.0 °C(Predicted)
Density 
1.151±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.65±0.10(Predicted)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
25-50
Safety Statements 
45-61
RIDADR 
UN2811
HS Code 
2933998090
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(R)-N-Boc-3-pyrrolidineacetic acid Usage And Synthesis

Synthesis

(R)-N-Boc-3-pyrrolidineacetic acid is synthesised using Di-tert-butyl dicarbonate as raw material by chemical reaction. The specific synthesis steps are as follows:
A solution of 4.95 g of the preceding step product in 50 ml of dichloromethane and 25 ml of trifluoroacetic acid is stirred at room temperature for 3 h. and concentrated. The residue is dissolved in 40 ml of dioxan and 40 ml of 1N NaOH, treated at room temperature with 4.3 g of di-tert-butyl dicarbonate in 40 ml of dioxan and stirred for 1.5 h. The reaction mixture is diluted with ether, the organic phase is washed with 1N NaOH and the aqueous phase is acidified with 3N HCl. Extraction of the aqueous phase with ether, washing, drying and concentration of the ether phase gives 0.72 g of tert-butyl(R)-3-carboxymethyl-pyrrolidine-1-carboxylate.

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