Diethyl methylmalonate Chemical Properties

Boiling point:

198-199 °C (lit.) 78-80 °C/10 mmHg

Density 

1.022 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.413(lit.)

Flash point:

170 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

1000mg/l

pka

13.13±0.46(Predicted)

form 

Liquid

Specific Gravity

1.013

color 

Clear colorless

PH

8 (1000mg/l, H2O, 20℃)

Water Solubility 

immiscible

BRN 

637028

InChIKey

UPQZOUHVTJNGFK-UHFFFAOYSA-N

LogP

1.256 (est)

CAS DataBase Reference

609-08-5(CAS DataBase Reference)

NIST Chemistry Reference

Propanedioic acid, methyl-, diethyl ester(609-08-5)

EPA Substance Registry System

Propanedioic acid, methyl-, diethyl ester (609-08-5)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29171990

MSDS

• Language:English Provider:Diethyl methylmalonate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Diethyl methylmalonate Usage And Synthesis

Chemical Properties

Colorless mobile liquid. Slightly soluble in water, soluble in alcohol and oils.

Physical properties

Colorless mobile liquid. Slightly soluble in water, soluble in alcohol and oils.

Uses

Diethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet

Uses

Diethyl methylmalonate was used to investigate the effect of direct supplementation of the medium with di-ester of methylmalonate on erythromycin fermentation in Saccharopolyspora erythraea mutB strain.

General Description

Diethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis.

Synthesis

Diethyl methylmalonate is produced by the following method:1) by condensing Ethylpropionate with Diethyloxalate, followed by heating of the reaction product. 2) from Diethylmalonate plus Sodium and Methyl iodide.

Diethyl methylmalonate(609-08-5)Related Product Information

• Dimethyl malonate
• 2-Hydroxyethyl methacrylate
• 2-Methylpropanedioic acid
• DIETHYL BROMOMALONATE
• Diethyl ethylmalonate
• Diethyl ketomalonate
• BUTYL OLEATE
• Tris(trimethylsilyl)phosphate
• Methylparaben
• Diethyl isopropylmalonate
• Diethyl allylmalonate
• DIETHYL DIETHYLMALONATE
• Diethyl dipropylmalonate
• Bensulfuron methyl
• Methyl acrylate
• Diethyl butylmalonate
• Diethyl 2-ethyl-2-phenylmalonate
• Diethyl phenylmalonate