Arprinocide Chemical Properties

Melting point:

245-246°

Boiling point:

504.6±60.0 °C(Predicted)

Density 

1.568 g/cm3

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

3.91±0.10(Predicted)

color 

Pale Yellow to Pale Beige

λmax

260nm(NaOH aq.)(lit.)

CAS DataBase Reference

55779-18-5(CAS DataBase Reference)

Safety Information

HS Code 

2933.59.3600

MSDS

• Language:English Provider:9-[(2-Chloro-6-fluorophenyl)methyl]purin-6-amine

Arprinocide Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Originator

Arprinocid,NANJING PHARMA

Uses

Arprinocide can be used as a Coccidiostat used in veterinary medicine.

Definition

ChEBI: Arprinocid is a member of 6-aminopurines.

Manufacturing Process

To a solution of potassium t-butoxide in absolute ethanol slowly adding dry adenine. This mixture was stirred for about 2 h, and then 2-chloro-6- fluorobenzyl chloride was added over a period of about 4 h. The resulting mixture was heated to reflux with stirring and allowed to react for about 42 h, after which it was cooled to about 10°C. The crude product thus formed was isolated by filtration and then washed with ice cold ethanol and ice cold water to yield a 6-amino-9-(2-chloro-6-fluorobenzyl)purine.

brand name

Arpocox (Merck).

Therapeutic Function

Coccidiostatic

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 960, 1978 DOI: 10.1021/jo00399a034

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