Felodipine Chemical Properties

solubility 

DMSO: 28 mg/mL

form 

solid

color 

light yellow

BCS Class

2

CAS DataBase Reference

86189-69-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

RTECS 

US7968700

MSDS

• Language:English Provider:SigmaAldrich

Felodipine Usage And Synthesis

Uses

Vasodilator.

brand name

Plendil (AstraZeneca).

Clinical Use

Calcium-channel blocker:
Hypertension
Angina

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
Antifungals: metabolism inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration possibly increased by ritonavir; use with caution with telaprevir.
Grapefruit juice: concentration increased - avoid concomitant use.
Tacrolimus: possibly increased tacrolimus concentration

Metabolism

Felodipine is metabolised in the liver and all identified metabolites are devoid of vasodilating properties. Approximately 70% of a given dose is excreted as metabolites in the urine and about 10% with the faeces. Less than 0.5% of the dose is excreted unchanged in the urin

Felodipine(86189-69-7)Related Product Information

• Poly(dimethylsiloxane)
• Dimethyl fumarate
• Dimethyl sulfoxide
• Dimethyl sulfate
• Dichlorodimethylsilane
• Dimethyl ether
• Dimethyl carbonate
• N,N-Dimethylacetamide
• ETHANE
• Chlorodimethylphenylsilane
• Dichlorodiphenylsilane
• N,N-Dimethylformamide
• Methyl
• FELODIPINE IMP.C ( EP) :DIETHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
• Methyl bromide
• FELODIPINE IMP.A ( EP) :ETHYL METHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE
• Bicalutamide
• (RS)-Felodipine,dl-Felodipine,Felodipine