- Product Name:
- Glucitol, 1-deoxy-1-(methylamino)-, D-
- D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
- Product Categories:
- Anilines, Aromatic Amines and Nitro Compounds
- Diagnostic agents
- Mol File:
Meglumine Chemical Properties
- Melting point:
- 129-131.5 °C(lit.)
- -16.5 º (c=10, H2O, on dry sub)
- Boiling point:
- 331.88°C (rough estimate)
- 1.2669 (rough estimate)
- refractive index
- -16.5 ° (C=2, H2O)
- storage temp.
- Store below +30°C.
- H2O: 0.1 g/mL, clear, colorless
- pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
- Crystalline Powder
- White to almost white
- 11 (10g/l, H2O, 20℃)
- optical activity
- [α]20/D 16.5±0.5°, c = 2% in H2O
- Water Solubility
- 100 g/100 mL (25 ºC)
- Air Sensitive & Hygroscopic
- NIST Chemistry Reference
- EPA Substance Registry System
- Meglumine (6284-40-8)
Meglumine Usage And Synthesis
white to almost white crystalline powder
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
excipient in cosmetics and X-ray contrast media
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg
Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
- FLUNIXIN MEGLUMINE IMP. C (EP): ETHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE
- gadoterate meglumine
- losulamide meglumine
- FLUNIXIN MEGLUMINE SALT,FLUNIXINE MEGLUMINE SALT,FLUNIXIN MEGLUMINE
- MEGLUMINE - REFERENCE SPECTRUM
- meglumine cyclic adenylate
- MEGLUMINE DIATRIAZOATE
- Flumixin meglumine
- Diatrizoate meglumine (USP),MEGLUMINE DIATRIZOATE,DIATRIZOATE MEGLUMINE,diatrizoic acid meglumine salt
- sulfalene meglumine
- gadolinium DOTA meglumine
- Flunixin meglumine
- iodipamide meglumine salt,meglumine iodipamide
- iodoxamic acid meglumine salt
- meglumine ioserinate
- N-METHYL GLUCAMINE ANTIMONIATE / MEGLUMINE ANTIMONIATE