OPIPRAMOL
OPIPRAMOL Basic information
- Product Name:
- OPIPRAMOL
- Synonyms:
-
- NSC 169867
- OPIPRAMOL
- 4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol
- N-[3-[4-(2-hydroxyethyl)piperazino]propyl]iminostilbene
- 1-Piperazineethanol, 4-3-(5H-dibenzb,fazepin-5-yl)propyl-
- 4-(3-(DIBENZ(B,F)AZEPIN-5-YL)PROPYL)-1-PIPERAZINEETHANOL
- G-33040
- GR-33040
- CAS:
- 315-72-0
- MF:
- C23H29N3O
- MW:
- 363.5
- EINECS:
- 206-254-0
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 315-72-0.mol
OPIPRAMOL Chemical Properties
- Melting point:
- 100-1010C
- Boiling point:
- 494.88°C (rough estimate)
- Density
- 1.0920 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble
- pka
- pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain)
- form
- Solid
- color
- Light yellow to yellow
- BRN
- 627076
OPIPRAMOL Usage And Synthesis
Chemical Properties
Crystalline Solid
Originator
Insidon,Geigy,W. Germany,1962
Uses
Antidepressant; antipsychotic
Definition
ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.
Manufacturing Process
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
Therapeutic Function
Antidepressant, Antipsychotic
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