OPIPRAMOL Chemical Properties

Melting point:

100-1010C

Boiling point:

494.88°C (rough estimate)

Density 

1.0920 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

-20°C Freezer

solubility 

Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble

pka

pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain)

BRN 

627076

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

1

RTECS 

TL8750000

OPIPRAMOL Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Insidon,Geigy,W. Germany,1962

Uses

Antidepressant; antipsychotic

Definition

ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.

Manufacturing Process

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.

Therapeutic Function

Antidepressant, Antipsychotic

OPIPRAMOL(315-72-0)Related Product Information

• Iminostilbene
• OPIPRAMOL HCL
• OPIPRAMOL-D4
• OPIPRAMOL DIHYDROCHLORIDE
• DESHYDROXYETHYL OPIPRAMOL
• OPIPRAMOL
• OPIPRAMOL DIHYDROCHLORIDE
• Opipramol-D8