Flupirtine Chemical Properties

Melting point:

115-116°

Boiling point:

445.15°C (rough estimate)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Soluble in DMSO

form 

Powder

pka

12.19±0.70(Predicted)

Water Solubility 

1g/L(temperature not stated)

Safety Information

Toxicity

LD50 orally in mice, rats: 617, 1660 mg/kg (Jakovlev)

MSDS

• Language:English Provider:Ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

Flupirtine Usage And Synthesis

Chemical Properties

Crystallized from isopropanol, melting point 115-116°C. 5% ethanol solution is colorless, but turns green after exposure to air for 20h. Acute toxicity LD50 mice, rats (mg/kg): 617, 1660 oral. Flupirtine Hydrochloride (Flupirtine Hydrochloride): C15 H17FN4O2?HCl. crystallized from water, melting point 214-215°C. Flupirtine Maleate (Flupirtine Maleate): C15H17FN4O2?C4H4O4.[75507-68-5]. Colorless crystals from isopropanol, melting point 175.5 to 176°C. A mixture of crystalline A and B; preferably containing 60%-90% A.

Uses

Analgesic.

Uses

Therapeutic use of Flupirtine was discontinued due to drug induced liver injury (DILI). Since the mechanism of action is not related to its adverse effects, it is important to focus on chemical modifications.

Definition

ChEBI: N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester is an aminopyridine.

Clinical Use

Flupirtine maleate is an analgesic with an unknown mode of action. It is used in single doses of 100 mg orally and 150 mg rectally for the treatment of different pain conditions.

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