Diphenic acid Chemical Properties

Melting point:

227-229 °C(lit.)

Boiling point:

345.05°C (rough estimate)

Density 

1.2695 (rough estimate)

refractive index 

1.5389 (estimate)

storage temp. 

Store below +30°C.

solubility 

almost transparency in Methanol

form 

powder to crystal

pka

pKa 3.20(H2O t=23.0) (Uncertain);5.06(H2O t=23.0) (Uncertain)

color 

White to Orange to Green

PH

4-5 (H2O, 20℃)

Water Solubility 

insoluble (20 ºC)

Merck 

14,3310

BRN 

2053625

InChIKey

GWZCCUDJHOGOSO-UHFFFAOYSA-N

CAS DataBase Reference

482-05-3(CAS DataBase Reference)

NIST Chemistry Reference

2,2'-Biphenyldicarboxylic acid(482-05-3)

EPA Substance Registry System

[1,1'-Biphenyl]-2,2'-dicarboxylic acid (482-05-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-37

WGK Germany 

3

Autoignition Temperature

390 °C

TSCA 

Yes

HS Code 

29173980

MSDS

• Language:English Provider:2,2'-Biphenyldicarboxylic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Diphenic acid Usage And Synthesis

Description

2,2’Dicarboxybiphenyl acid is also known as diphenic acid, being a useful pharmaceutical intermediate and used in the synthesis of dyes. Diphenic acid derivatives have attracted great attention due to its possession of useful therapeutic properties. Many diphenic acids derivatives have the potential of lowering the risk of chronic diseases such as cancer, cardiovascular diseases and other pathologies. It is applied in many herbs and components of food. Diphenic acids derivatives can usually be found in fruits like blackberry, raspberry and strawberry.

Sources

https://www.alfa.com/zh-cn/catalog/A15863/
https://www.tandfonline.com/doi/abs/10.1080/00397911.2017.1298805?journalCode=lsyc20

Chemical Properties

Off-white powder

Definition

ChEBI: Diphenic acid is a dicarboxylic acid. It is a conjugate acid of a diphenate(1-). It derives from a hydride of a biphenyl.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2876, 1960 DOI: 10.1021/ja01496a051
Organic Syntheses, Coll. Vol. 1, p. 222, 1941
Synthesis, p. 731, 1982

Purification Methods

Crystallise diphenic acid from water. Hot Ac2O provides the anhydride below. [Beilstein 9 H 922, 9 IV 3552.]

Diphenic acid(482-05-3)Related Product Information

• Diethyl phthalate
• Potassium hydrogen phthalate
• Terephthalic acid
• Folic acid
• Dimethyl phthalate
• Citric acid
• Phthalic acid
• Isophthalic acid
• Diisobutyl phthalate
• Bis(2-ethylhexyl) phthalate
• 4,4'-Bis(methoxymethyl)-1,1'-biphenyl
• Dibutyl phthalate
• Hyaluronic acid
• Biphenyl
• Ethyl 2-(Chlorosulfonyl)acetate
• OXALIC ACID
• Ascoric Acid
• CHARTREUSIN