o-Cresolphthalein Complexone Chemical Properties

Melting point:

181-185 °C (dec.)(lit.)

Boiling point:

892.1±65.0 °C(Predicted)

Density 

1.515±0.06 g/cm3(Predicted)

storage temp. 

Store below +30°C.

solubility 

NaOH: soluble50mg/mL

form 

Powder

pka

1.47, 8.24(at 25℃)

color 

white to off-white

PH Range

Colorless (8.2) to red (9.8)

Water Solubility 

SLIGHTLY SOLUBLE

λmax

575nm, 377nm

BRN 

381994

Stability:

Stable. Incompatible with strong oxidizing agents.

Major Application

Sensors, photoconductors, copying materials, rubber, body fiuid testing, determination of calcium, magnesium, tin, method for measuring urea nitrogen, liposomal construct for diagnostic use, cardiovascular disease, antibacterial agent

InChIKey

IYZPEGVSBUNMBE-UHFFFAOYSA-N

EPA Substance Registry System

Glycine, N,N'-[(3-oxo-1(3H)-isobenzofuranylidene)bis[(6-hydroxy-5-methyl-3,1-phenylene)methylene]]bis[N-(carboxymethyl)- (2411-89-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

TSCA 

Yes

HS Code 

29322980

MSDS

• Language:English Provider:3',3"-Bis[[bis(carboxymethyl)amino]methyl]-5', 5"-dimethylphenolphthalein
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

o-Cresolphthalein Complexone Usage And Synthesis

Chemical Properties

White powder

Uses

Indicator for complexometric titration of Mg, Ca, Sr and Ba. It is used as an alkaline earth metal ion indicator. Suggested to be colorless at pH 11, but turns pink in the presence of alkaline earth metals. Also utilized in an auto analyzer to determine serum calcium.

Purification Methods

o-Cresolphthalein (a complexon precursor without the two bis-carboxymethylamino groups) is a contaminant and is one of the starting materials. It can be removed by dissolving the reagent in H2O and adding a 3-fold excess of sodium acetate and fractionally precipitating it by dropwise addition of HCl to the clear filtrate. Wash the precipitate with cold H2O and dry the monohydrate at 30o in a vacuum. The pure material gives a single spot on paper chromatography (eluting solvent EtOH/water/phenol, 6:3:1, and developing with NaOH). [Anderegg et al. Helv Chim Acta 37 113 1954.] It complexes with Ba, Ca, Cd, Mg and Sr. [Beilstein 18 III/IV 8141.]

o-Cresolphthalein Complexone(2411-89-4)Related Product Information

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