Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Digestive system drugs >  Gastrointestinal antispasmodic drugs >  Propantheline bromide

Propantheline bromide

Basic information Safety Supplier Related

Propantheline bromide Basic information

Product Name:
Propantheline bromide
Synonyms:
  • nci-c56257
  • neometantyl
  • neopepulsan
  • pantas
  • pantheline
  • pervagal
  • Probanthine
  • pro-banthine
CAS:
50-34-0
MF:
C23H30BrNO3
MW:
448.39
EINECS:
200-030-6
Product Categories:
  • PROBANTHINE
  • Drug bulk
  • Miscellaneous
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
50-34-0.mol
More
Less

Propantheline bromide Chemical Properties

Melting point:
159-161°C
Density 
1.2916 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white to off-white
Water Solubility 
>=10 g/100 mL at 21 ºC
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
EPA Substance Registry System
Propantheline bromide (50-34-0)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
BP8249200
HS Code 
2932992000

MSDS

More
Less

Propantheline bromide Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder.

Uses

anticholinergic

Uses

A muscarinic acetylcholine receptor antagonist

brand name

Pro-Banthine (Searle).

General Description

Propantheline bromide,2-hydroxy-ethyl)diisopropylmethylammonium bromidexanthene-9-carboxylate (Pro-Banthine), is prepared in amanner exactly analogous to that used for methanthelinebromide. It is a white, water-soluble, crystalline substance,with properties quite similar to those of methantheline bromide.Its chief difference from methantheline bromide is inits potency, which has been estimated variously to be 2 to5 times as great.

General Description

White crystals or white powder. Melting point 159-161°C .Used therapeutically as an anticholinergic.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma.

Fire Hazard

Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible.

Veterinary Drugs and Treatments

In small animal medicine propantheline bromide has been used for its antispasmodic/antisecretory effects in the treatment of diarrhea. It is also employed in the treatment of hyperreflexic detrusor or urge incontinence and as oral treatment in anticholinergic responsive bradycardias. In horses, propantheline has been used intravenously to reduce colonic peristalsis and for relaxing the rectum to allow easier rectal examination and surgery.

Propantheline bromide Preparation Products And Raw materials

Raw materials

Propantheline bromide Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
CHANGZHOU TIANHUA PHARMACEUTICAL CO.,LTD.
Tel
+86-519-82891186;82899734
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com