2-(2-Chlorophenyl)acetonitrile Chemical Properties

Melting point:

24 °C (lit.)

Boiling point:

240-242 °C (lit.)

Density 

1

refractive index 

1.5425-1.5445

Flash point:

>110°C

storage temp. 

Sealed in dry,Room Temperature

Water Solubility 

Insoluble in water

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

FreezingPoint 

22.0 to 25.0 ℃

BRN 

2043683

Exposure limits

NIOSH: IDLH 25 mg/m3

CAS DataBase Reference

2856-63-5(CAS DataBase Reference)

NIST Chemistry Reference

2-Chlorobenzyl cyanide(2856-63-5)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

36/37/38-23/24/25

Safety Statements 

45-36/37/39-28B-26-22

RIDADR 

3276

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269095

MSDS

• Language:English Provider:2-Cyanobenzyl chloride
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-(2-Chlorophenyl)acetonitrile Usage And Synthesis

Chemical Properties

CLEAR SLIGHTLY YELLOW LIQUID AFTER MELTING

Uses

2-Chlorobenzyl cyanide was used in the synthesis of clopidogrel, platelet aggregation inhibitor.

Synthesis

GENERAL METHODS: A mixture of MOM-ether (1 mmol) and tetrabutylammonium cyanide (2 mmol) was added to [Hmim][NO3] (0.4 mmol) and the reaction was carried out under microwave irradiation (the reaction temperature was maintained at 135 °C and the power at 170 W). The reaction process was monitored by thin-layer chromatography (TLC) and the eluent was hexane/ethyl acetate (5:1). After completion of the reaction, the mixture was extracted with ether (3 × 10 mL). The organic phases were combined and dried with anhydrous Na2SO4, followed by rotary evaporation to remove the solvent to give the crude product. The crude product was purified by neutral alumina column chromatography with hexane/ethyl acetate (5:1, 75 mL) as the eluent to give high purity o-chlorophenylacetonitrile, the spectral data of which were in agreement with those reported in the literature.

References

[1] Tetrahedron Letters, 2010, vol. 51, # 25, p. 3274 - 3276
[2] Tetrahedron Letters, 2014, vol. 55, # 32, p. 4424 - 4426

2-(2-Chlorophenyl)acetonitrile(2856-63-5)Related Product Information

• Calcium chloride
• Mepiquat chloride
• Acetonitrile
• Choline chloride
• 2-Chlorobenzoic acid
• Benzyl chloride
• Ammonium chloride
• Polyvinyl chloride
• 2-Chlorobenzaldehyde
• Sodium chloride
• 2-Chlorophenylacetic acid
• 2-Chlorophenol
• 2,4-Dichlorophenylacetonitrile
• 2-CHLORO-6-FLUOROPHENYLACETONITRILE
• Glycolonitrile
• 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile
• 2,6-Dichlorobenzyl acetonitrile
• 2-Chlorophenyl cyclopentyl ketone