S(-)-BAY K 8644 Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: slightly soluble

form 

solid

color 

yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933399990

MSDS

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S(-)-BAY K 8644 Usage And Synthesis

Uses

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats.

Definition

ChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.

General Description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺?channel activator. It is an enantiomer of Bay K 8644.

Biological Activity

L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

storage

Store at +4°C

S(-)-BAY K 8644(98625-26-4)Related Product Information

• 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid
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• Phenibut
• BAY K-8644 (+/-),(+/-)-BAY K 8644,(RS)-BAY K 8644,(+/-)-BAY K8644 CALCIUM SLOW CHANNEL
• 3-[(2-TRIFLUOROMETHYL)PHENYL]-1-PROPENE
• 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL
• 1-NITRO-2-METHYL-BUTANE
• o-(trifluoromethyl)phenethylamine
• METHYL (R)-3-PHENYLBUTYRATE
• S(-)-BAY K 8644
• 4-AMINO-3-PHENYL-1-BUTANOL
• 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
• METHYL 4-NITROBUTYRATE
• BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID
• R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE,(+/-)-BAY K 8644, 0 TO 5 °C,R(+)-BAY K 8644 98% 0 C,R(+)-BAY K 8644
• BAY K-8644 (+/-),(+/-)-BAY K 8644
• (+/-) CAGED BAY K 8644
• R(+)-BAY K 8644, CALCIUM CHANNEL