Basic information Safety Supplier Related

S(-)-BAY K 8644

Basic information Safety Supplier Related

S(-)-BAY K 8644 Basic information

Product Name:
S(-)-BAY K 8644
Synonyms:
  • S(-)-BAY K 8644
  • (4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
  • S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
  • (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
  • s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
  • [4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
  • BAY-r-5417
  • R-5417
CAS:
98625-26-4
MF:
C16H15F3N2O4
MW:
356.3
Product Categories:
  • Calcium channel
Mol File:
98625-26-4.mol
More
Less

S(-)-BAY K 8644 Chemical Properties

storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
solid
color 
yellow
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933399990

MSDS

More
Less

S(-)-BAY K 8644 Usage And Synthesis

Uses

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats.

Definition

ChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.

General Description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+?channel activator. It is an enantiomer of Bay K 8644.

Biological Activity

L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

storage

Store at +4°C

S(-)-BAY K 8644Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Email
mychess007@163.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com