4-Iodoanisole Chemical Properties

Melting point:

50-53 °C(lit.)

Boiling point:

237 °C726 mm Hg(lit.)

Density 

1.7904 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in ethanol, ether, chloroform.

form 

Crystalline Powder and Chunks

color 

Off-white to brown

Sensitive 

Light Sensitive

BRN 

1906692

InChIKey

SYSZENVIJHPFNL-UHFFFAOYSA-N

CAS DataBase Reference

696-62-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-iodo-4-methoxy-(696-62-8)

EPA Substance Registry System

Benzene, 1-iodo-4-methoxy- (696-62-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

F 

8

TSCA 

Yes

HS Code 

29093090

MSDS

• Language:English Provider:4-Iodoanisole
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• Language:English Provider:SigmaAldrich
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4-Iodoanisole Usage And Synthesis

Description

4-Iodoanisole (chemical formula: C7H7IO) is an organic compound being soluble in ethanol, ether and chloroform. It has a wide range of medicals industrial applications. For example, it can be used as human and animal nutrition products, antiseptics, disinfectants, pharmaceutical intermediates, polarizing films for liquid crystal display (LCD) chemicals. Its iodine derivatives can also be used as organic building blocks and analytic reagents.

References

https://www.fishersci.pt/shop/products/4-iodoanisole-98-7/11480113

Chemical Properties

off-white to brown crystalline powder and chunks. Melting point 51-52 ℃, boiling point 237 ℃ (96.8kPa). Soluble in organic solvents such as alcohol and ether, but insoluble in water. Iodine can be easily separated and analyzed by light.

Uses

4-Iodoanisole is used in wide range of medicals industrial applications as well as in human and animal nutrition products, pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals. Iodine derivatives are also used as organic building blocks, analytical reagents.

Preparation

4-Iodoanisole is synthesized by the reaction of anisole with iodine chloride. Add anisole to glacial acetic acid, stir and slowly add iodine chloride. After the addition was completed, the temperature was refluxed for 3.5h. Cool, pour into ice water, and precipitate p-iodoanisole. After it was separated, the free iodine was washed with 5% sodium sulfite, then washed with water, distilled under reduced pressure, and the fractions with a boiling point of 140-160 °C (5.33 kPa) were collected and cooled to 0 °C for filtration. Wash with methanol and recrystallize to obtain the finished product.

Definition

ChEBI: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein) is a member of methoxybenzenes.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 2058, 1993 DOI: 10.1021/jo00060a020
Tetrahedron Letters, 27, p. 3497, 1986 DOI: 10.1016/S0040-4039(00)84832-7

Purification Methods

Crystallise 4-iodoanisole from aqueous EtOH and/or distil it under vacuum. [Beilstein 6 H 208, 6 I 109, 6 II 199, 6 III 744, 6 IV 1075.]

4-Iodoanisole(696-62-8)Related Product Information

• Dimethyl ether
• 4-Methylanisole
• 1-Methoxy-2-propyl acetate
• p-Anisidine
• 4-Iodophenoxyacetic acid
• 1-Methoxy-2-propanol
• 4-Iodobenzoic acid
• 1-Bromo-4-iodobenzene
• 4-Methoxyphenol
• Anisole
• (Diacetoxyiodo)benzene
• 4-IODOBENZALDEHYDE
• ROSE BENGAL
• ERYTHROSIN B
• 4-Iodo-3-Nitroanisole 3-Nitro-4-Iodoanisole,3-Nitro-4-Iodoanisole
• alpha,alpha,alpha-trifluoro-4-iodoanisole
• 4-IODODIPHENYL ETHER
• 4-Iodophenetole