Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Diagnostic agents >  Medical Imaging Drugs >  Iodixanol

Iodixanol

Basic information Safety Supplier Related

Iodixanol Basic information

Product Name:
Iodixanol
Synonyms:
  • Acupaque
  • DU-6807
  • 5-[acetyl-[3-[N-acetyl-3,5-bis[(2,3-dihydroxypropylamino)-oxomethyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
  • Iodixanol (200 mg)
  • 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetyliMino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-
  • odixanol
  • IODIXANOL
  • 1,3-benzenedicarboxamide,5,5’-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis
CAS:
92339-11-2
MF:
C35H44I6N6O15
MW:
1550.18
EINECS:
618-837-0
Product Categories:
  • Aromatics
  • Diagnostic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 92339-11-2
Mol File:
92339-11-2.mol
More
Less

Iodixanol Chemical Properties

Melting point:
262-267°C (dec.)
Boiling point:
1250.9±65.0 °C(Predicted)
Density 
1.266 ±0.003
vapor pressure 
0Pa at 20℃
refractive index 
n 1.4128 ±0.0003
storage temp. 
Refrigerator
solubility 
Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
pka
11.04±0.46(Predicted)
color 
White
LogP
0.7
EPA Substance Registry System
1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
More
Less

Safety Information

HS Code 
2924296000
Hazardous Substances Data
92339-11-2(Hazardous Substances Data)
Toxicity
LD50 i.v. in mice: 21 gI/kg (Palmers)

MSDS

More
Less

Iodixanol Usage And Synthesis

Chemical Properties

White Solid

Originator

OptiPrep,Nycomed Pharma,Norway

Uses

Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).

Definition

ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Manufacturing Process

Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal (0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2 (42.5 ml) was added through a dropping funnel over 1 hour. The solution was heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g) was suspended in acetic anhydride (480 ml) and heated to 50°C. Concentrated sulfuric acid (3 ml) was then added. The starting material was dissolved after a few minutes, and the reaction mixture was heated at 60°C for 75 min. After cooling the residue dissolved in methanol (300 ml) with water (150 ml) the solution was heated to 50°C and the pH adjusted to about 10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and the hydrolysis was complete. The reaction mixture was cooled to 20°C and neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido- 2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophtalamide (304 g) was added after two hours of stirring. All solids were allowed to dissolve overnight before cooling to 30°C and adjustment to pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the solution after further cooling to 15°C, and the reaction was allowed to proceed for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was obtained.

brand name

Visipaque (GE Healthcare).

Therapeutic Function

Diagnostic aid

General Description

Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.

Iodixanol Preparation Products And Raw materials

Raw materials

IodixanolSupplier

Xianning Shen Lan Biomedical Research and Development Co., Ltd. Gold
Tel
18171815831
Email
1341138380@qq.com
Hunan Eurasian Pharmaceutical Co. Ltd. Gold
Tel
0592-5789919 13328776692
Email
2851802016@qq.com
Hubei widely chemical technology Co., Ltd. Gold
Tel
027-83778895 18602735115
Email
18602735115@163.com
Wuhan Penglei Biological Technology Co., Ltd. Gold
Tel
18672616696
Email
229092275@qq.com
Wuhan Augda Biotechnology Co., Ltd Gold
Tel
15071299552
Email
262933239@qq.com