4-BROMO-3-METHOXYANILINE Chemical Properties

Melting point:

96-100 °C(lit.)

Boiling point:

272.1±20.0 °C(Predicted)

Density 

1.531±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.47±0.10(Predicted)

form 

solid

color 

Beige

BRN 

2690835

InChI

InChI=1S/C7H8BrNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3

InChIKey

RUTNWXBHRAIQSP-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(Br)C(OC)=C1

CAS DataBase Reference

19056-40-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-43

Safety Statements 

36/37

RIDADR 

UN2811

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-BROMO-3-METHOXYANILINE Usage And Synthesis

Chemical Properties

White to brown crystalline powder

Uses

4-Bromo-3-(methyloxy)aniline is a useful reagent for organic synthesis and other chemical processes. It is used in the preparation of 4-Anilino substituted α-carboline compounds as active Brk inhibitors (breast tumor kinase) which are interesting targets for cancer therapy.

Synthesis

General procedure for the synthesis of 4-bromo-3-methoxyaniline from 2-bromo-5-nitroanisole: To a solution of 1-bromo-2-methoxy-4-nitrobenzene (23 g, 99.6 mmol) in tetrahydrofuran (THF, 200 mL) was added ammonium chloride (64 g, 1.2 mol) and zinc powder (78.1 g, 1.2 mol). The reaction mixture was heated to reflux overnight. After completion of the reaction, the mixture was cooled to room temperature, filtered through a bed of diatomite (Celite) and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between water (200 mL) and ethyl acetate (200 mL). The organic layer was separated, washed with brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromo-3-methoxyaniline (17.4 g, 87% yield) as a yellow solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz): δ 7.1 (d, 1H), 6.31 (s, 1H), 6.1 (d, 1H), 5.27 (bs, 2H), 3.72 (s, 3H) ppm.

References

[1] Patent: US4882354, 1989, A
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 194
[3] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988
[4] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 127
[5] Tetrahedron Letters, 1995, vol. 36, # 42, p. 7583 - 7586

4-BROMO-3-METHOXYANILINE(19056-40-7)Related Product Information

• 2-BROMO-5-NITROANISOLE
• 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE
• 2-BROMO-5-NITROETHOXYBENZENE
• 4-BROMO-3-METHOXYANILINE
• 2-BROMO-5-METHOXYANILINE
• 5-Bromo-2-methoxyaniline, HCl
• 4-BROMO-2-METHOXYANILINE[2-AMINO-5-BROMOANISOLE] ,4-BROMO-2-METHOXYANILINE
• 2-BROMO-4-METHOXYANILINE
• 2-Bromo-5-methoxyaniline, HCl
• 5-BROMO-2-METHOXYANILINE
• 2-Bromoanisole
• m-Anisidine
• N-(2,4-DIBROMO-5-METHOXYPHENYL)CYCLOHEXYLFORMAMIDE
• 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE
• 3-Bromo-4-methoxyaniline hydrochloride
• 3-BROMO-4-METHOXYANILINE
• 2-BROMO-6-METHOXYANILINE
• 3-Bromo-4-methoxyaniline hydrochloride