Risdiplam Chemical Properties

Density 

1.50±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO

pka

9.41±0.20(Predicted)

form 

solid

color 

Light yellow to yellow

InChI

InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3

InChIKey

ASKZRYGFUPSJPN-UHFFFAOYSA-N

SMILES

C12C=CC(N3CC4(CC4)NCC3)=CN1C(=O)C=C(C1=NN3C=C(C)N=C3C(C)=C1)N=2

Risdiplam Usage And Synthesis

Description

Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.

Chemical Properties

light yellow powder to yellow powder

Uses

Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.

Side effects

Body aches or pain, chest pain or tightness, chills, cough, ear congestion, fever, headache, loss of voice, runny or stuffy nose, sneezing, sore throat, trouble breathing, unusual tiredness or weakness and so on.

storage

0-4℃ for short term (days to weeks) or -20℃ for long term (months)