Cell senescence beta-galactosidase staining kit CAS#:

ChemicalBook > Product Catalog > Biologics > Biochemical Reagent Kit > Cell senescence beta-galactosidase staining kit

Cell senescence beta-galactosidase staining kit

Basic information Description Background References Safety Supplier Related

Cell senescence beta-galactosidase staining kit Basic information

Product Name:

Cell senescence beta-galactosidase staining kit

Synonyms:

Senescence β-Galactosidase Staining Kit

MW:

Mol File:

Mol File

Less

Cell senescence beta-galactosidase staining kit Usage And Synthesis

Description

The Senescence β-Galactosidase Staining Kit is designed to conveniently provide reagents needed to detect β-galactosidase activity at pH 6, a known characteristic of senescent cells. Papers have published using this kit in both cells and frozen tissue. The kit includes all reagents necessary for this assay.

Background

Limited capacity to replicate is a defining characteristic of most normal cells and culminates in senescence, an arrested state in which the cell remains viable. Senescent cells are not stimulated to divide by serum or passage in culture, and senescence invokes a specific cell cycle profile that differs from most damage-induced arrest processes or contact inhibition. An enlarged cell size, expression of pH-dependent β-galactosidase activity, and an altered pattern of gene expression further characterize senescent cells.

References

[1] Goldstein, S. (1990) Science 249, 1129-33.
[2] Sherwood, S. W. et al. (1988) Proc. Natl. Acad. Sci., USA 85, 9086-90.
[3] Dimri, G. et al. (1995) Proc. Natl. Acad. Sci., USA 92, 9363-7.
[4] Cristofalo, V. J. et al. (1998) Crit. Rev. Eukaryot Gene Expr. 8, 43-80.
[5] Linskens, M. H. et al. (1995) Nucleic Acid Res. 23, 3244-51.

Cell senescence beta-galactosidase staining kitSupplier

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-02161998551 13122364865
Email: sale1@shzysw.net

Less