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Swertiamarine

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Swertiamarine Basic information

Product Name:
Swertiamarine
Synonyms:
  • (4ar-(4a-alpha,5-beta,6-alpha))-ranosyloxy)-4a-hydroxy
  • 1h,3h-pyrano(3,4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopy
  • 1H,3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.alpha.-hydroxy-,[4ar-(4.alpha.-.alpha.,5-.beta.,D-.alpha.)]-
  • 3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.1H
  • Swertiamari
  • 4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosyloxy)-4a-hydroxy-3h-pyrano(1
  • glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-,(4aR,5R, 6S)-
  • Swertiamarin(6CI,7CI,8CI)
CAS:
17388-39-5
MF:
C16H22O10
MW:
374.34
Product Categories:
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Sugars, Carbohydrates & Glucosides
Mol File:
17388-39-5.mol
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Swertiamarine Chemical Properties

Melting point:
113-114°
alpha 
D20 -127° (c = 1 in 96% ethanol)
Boiling point:
649.3±55.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO : 250 mg/mL (667.84 mM; Need ultrasonic)
pka
11.56±0.60(Predicted)
color 
White to Yellow to Orange
λmax
238nm(MeOH)(lit.)
Merck 
14,9010
BRN 
55278
Stability:
Hygroscopic
InChIKey
HEYZWPRKKUGDCR-QBXMEVCASA-N
CAS DataBase Reference
17388-39-5(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
UQ1366700
HS Code 
29389090
Toxicity
mouse,LD50,intraperitoneal,> 8gm/kg (8000mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982.
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Swertiamarine Usage And Synthesis

Uses

Swertimarine is an extract from Enicostemma littorale which is an herb used in the treatment of type 1 and 2 diabetes. Used to sensitize the cells to hypolipidemic conditions and insulin.

Definition

ChEBI: Swertiamarin is a glycoside.

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