4-Hydroxyisophthalaldehyde Chemical Properties

Melting point:

109°C

Boiling point:

266.0±25.0 °C(Predicted)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

pka

5.98±0.18(Predicted)

color 

White to Orange to Green

CAS DataBase Reference

3328-70-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2912490090

MSDS

• Language:English Provider:SigmaAldrich

4-Hydroxyisophthalaldehyde Usage And Synthesis

Description

4-hydroxyisophthalaldehyde is a vital organic compound. It could be used to synthesise NIR fluorescent fluorophore QCy7-Ethyl[1]. Additionally, 4-hydroxyisophthalaldehyde could be obtained from 4-hydroxybenzaldehyde using the modified Duff reaction[2].

References

[1] A. Anderson. “A Convenient One-Step Synthesis of 2-Hydroxy-1,3,5-Benzenetricarbaldehyde.” Synthetic Communications 30 1 (2000): 3227–3232.
[2] Zhiwei Gao . “A unique off-on near-infrared cyanine-based probe for imaging of endogenous alkaline phosphatase activity in cells and in vivo.” Sensors and Actuators B: Chemical 265 (2018): Pages 565-574.

4-Hydroxyisophthalaldehyde(3328-70-9)Related Product Information

• 5-Acetylsalicylamide
• METHYL 5-ACETYLSALICYLATE
• 5-Formylsalicylic acid
• ATRANORIN
• 4-HYDROXYISOPHTHALALDEHYDE
• 4-Hydroxyisophthalic acid
• FUMARPROTOCETRARIC ACID
• 1-(3-ACETYL-2,4,6-TRIHYDROXYPHENYL)ETHAN-1-ONE
• 5-ACETYLSALICYLIC ACID
• PSOROMIC ACID
• 5-Methyl-2-hydroxyisophthalaldehyde
• 2-HYDROXYISOPHTHALALDEHYDE
• m-Phthalaldehyde
• STICTIC ACID
• 4,6-DIBENZOYLRESORCINOL
• 5-CARBOXYVANILLIC ACID
• 4,6-DIACETYLRESORCINOL
• 3-FORMYL-4-HYDROXYBENZOIC ACID