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Dolutegravir 2-Desfluoro Impurity
Dolutegravir 2-Desfluoro Impurity Basic information
- Product Name:
- Dolutegravir 2-Desfluoro Impurity
- Synonyms:
-
- 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity
- Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
- Dolutegravir Impurity G
- Dolutegravir 2-Desfluoro Impurity
- 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
- (4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
- Dolutegravir Impurity 47
- Dolutegravir Impurity 50
- CAS:
- 1863916-88-4
- MF:
- C20H20FN3O5
- MW:
- 401.39
- Mol File:
- 1863916-88-4.mol
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Dolutegravir 2-Desfluoro Impurity Chemical Properties
- Boiling point:
- 675.7±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 4.50±1.00(Predicted)
- color
- Off-White to Light Brown
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Dolutegravir 2-Desfluoro Impurity Usage And Synthesis
Uses
Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Dolutegravir 2-Desfluoro ImpuritySupplier
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