L-745,870 TRIHYDROCHLORIDE Chemical Properties

Boiling point:

571.4±50.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

DMSO:16.5(Max Conc. mg/mL);50.49(Max Conc. mM)

pka

8.20±0.20(Predicted)

form 

Solid

color 

White to off-white

L-745,870 TRIHYDROCHLORIDE Usage And Synthesis

Uses

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.

Definition

ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines.

Biological Activity

A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.

L-745,870 TRIHYDROCHLORIDE(158985-00-3)Related Product Information

• hypochlorous acid
• 1-(2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraen-7-yl)-N,N-dimethyl-methanamine
• 1-(4-Chlorophenyl)piperazine dihydrochloride
• 1H-Pyrrolo[2,3-b]pyridine, 3-(1-piperazinylmethyl)-
• 3-METHYL-7-AZAINDOLE
• 3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE
• 7-Azaindole
• L-745,870 TRIHYDROCHLORIDE