ANGELIC ANHYDRIDE Chemical Properties

Boiling point:

108 °C / 13mmHg

Density 

1,02 g/cm³

refractive index 

1.4720-1.4750

storage temp. 

0-10°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

clear liquid

color 

Colorless to Light orange to Yellow

InChIKey

LIHLSLRANKCHLV-SFECMWDFSA-N

Safety Information

RIDADR 

3265

HS Code 

2916.19.5000

HazardClass 

8

PackingGroup 

III

ANGELIC ANHYDRIDE Usage And Synthesis

Uses

Angelic Anhydride is a reagent in the improved synthesis of angelate esters, which are the active chemical behind the strong pain-relieving and spasmolytic action of extracts from the plant butterbur.

Synthesis

Angelic anhydride (dahuric anhydride) was prepared as follows: to a solution of angelic acid (5 g, 50 mmol) in dichloromethane (100 mL) at room temperature was added N,N’ Dicyclohexylcarbodiimide (8.6 mL, 60% in xylene, 25 mmol). The reaction mixture was stirred at this temperature for 1 hour. The precipitate was filtered. The filtrate was concentrated in vacuum. The residue was purified by chromatography (petroleum ether/ethyl acetate 10:1) to give 4.3 g of the title compound dahuric anhydride as an oil (94%). ¹H NMR (300 MHz, CDCl₃)δ 6.376.25 (m, 2H), 2.06 (dq, J=7.4, 1.5 Hz, 6H), 1.971.93 (m, 6H).

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