Anilofos Chemical Properties

Melting point:

50～55℃

Boiling point:

443.6±55.0 °C(Predicted)

Density 

1.322±0.06 g/cm3(Predicted)

Flash point:

>100 °C

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

-0.48±0.50(Predicted)

form 

Solid

color 

White to off-white

BRN 

2395778

Major Application

agriculture
environmental

InChI

1S/C13H19ClNO3PS2/c1-10(2)15(12-7-5-11(14)6-8-12)13(16)9-21-19(20,17-3)18-4/h5-8,10H,9H2,1-4H3

InChIKey

NXQDBZGWYSEGFL-UHFFFAOYSA-N

SMILES

COP(=S)(OC)SCC(=O)N(C(C)C)c1ccc(Cl)cc1

CAS DataBase Reference

64249-01-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn;N,N,Xn

Risk Statements 

22-51/53

Safety Statements 

60-61

RIDADR 

UN 3077

WGK Germany 

2

RTECS 

TD5185000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LD50 orl-rat: 472 mg/kg PEMNDP 9,36,1991

MSDS

• Language:English Provider:S-(2-((4-Chlorophenyl)(1-methylethyl)amino)-2-oxoethyl) O,O-dimethyl phosphorodithioate

Anilofos Usage And Synthesis

Uses

Agricultural chemical.

Definition

ChEBI: Anilofos is an anilide.

Hazard

Moderately toxic by ingestion and skin con- tact.

Safety Profile

Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, POx, SOx, and Cl^-.

Synthesis

1. Synthesis of N-isopropyl-p-chloroaniline
Add p-chloroaniline, 2-bromopropane sequentially to the reaction kettle, heating and stirring, after reacting at a certain temperature for several hours, cooling, adding sodium hydroxide solution and stirring the stratification, the oil layer is washed with water to neutral, the aqueous layer is extracted with a solvent, combining the oil layers, desolventizing to get a purplish-red liquid or distillation under reduced pressure to get a colorless liquid with a yield of 95%-98% and purity of 95%-97%.
2. Synthesis of N-chloroacetyl-N-isopropyl-p-chloroaniline
N-isopropyl-p-chloroaniline, solvent, chloroacetyl chloride in turn into the reactor, heating and stirring, reaction at a certain temperature for a few hours, add water and stirring, layering, the oil layer washed with water for several times, the water layer was extracted with solvent, the oil layer was combined, the solvent was removed to obtain a light red solid. Yield 98%, purity 96% or more.
3. The synthesis of Sa taipa phosphorus
In the reaction kettle, add N-chloroacetyl-N-isopropyl-p-chloroaniline, acid-binding agent, solvent, and O, O-dimethyl dithiophosphoric acid, at a certain temperature, stirring reaction for a few hours, the end of the reaction add water and stirring, delamination, oil layer washed with water to neutral, desolvation of the finished product of Sabauphos, yield 88% ~ 90%, purity 87% ~ 90%.

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