LAURDAN Chemical Properties

Melting point:

88 °C(lit.)

Boiling point:

497.4±20.0 °C(Predicted)

Density 

0.987±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: soluble

pka

4.44±0.40(Predicted)

form 

Solid

color 

Off-White to Pale Brown

BRN 

7379104

Safety Information

WGK Germany 

3

F 

8-10

MSDS

• Language:English Provider:SigmaAldrich

LAURDAN Usage And Synthesis

Uses

N,N-Dimethyl-6-dodecanoyl-2-naphthylamine (Laurdan) is used as an environmentally sensitive probe for the labeling of plasmamembranes.

Uses

6-Dodecanoyl-N,N-dimethyl-2-naphthylamine is a fluorescent membrane probe used in phospholipid multilamellar aggregates which distinguishes between phase transitions, phase fluctuations and the coexistence of phase domains. Studies indicate that the bulky and highly hydrated polar head groups of glycosphingolipids interact well with 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine. The fluorescence is derived from the naphthalene moiety, in which a small dipole moment exists due to a partial charge separation between the 2-dimethylamino and the 6-carbonyl residues. This fluorescent tag is ideal to study dipolar relaxation because this compound emits different light depending on the environment it is in. For instance, 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine emits red light in a polar solvent and

Biological Activity

1-(6-(dimethylamino)naphthalen-2-yl) dodecan-1-one or Laurdan exhibits spectral sensitivity to phospholipid phase state. It also exhibits fluorescence property. Laurdan is implicated in bilayer property studies of natural and artificial membranes due to its sensitivity to solvent relaxation effect.

storage

Store at -20°C

LAURDAN(74515-25-6)Related Product Information

• N,N'-Ethylenebis(stearamide)
• (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
• N,N-Dimethylaniline
• N-Methylaniline
• N,N-Dimethylpropionamide
• N,N-DIMETHYL-2-NAPHTHYLAMINE
• LAURDAN
• PRODAN
• PATMAN
• 6-DIMETHYLAMINO-2-NAPHTHALDEHYDE
• BETA-NAPHTHYLPROPYLKETONE
• 2-NAPHTHALENAMINE, 6-METHYL-
• LAUROPHENONE