9-Fluorenone-2-carboxylic acid Chemical Properties

Melting point:

>300 °C (lit.)

Boiling point:

325.61°C (rough estimate)

Density 

1.2337 (rough estimate)

refractive index 

1.5400 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

form 

Fine Powder

pka

3.85±0.20(Predicted)

color 

Yellow

CAS DataBase Reference

784-50-9(CAS DataBase Reference)

NIST Chemistry Reference

9-Fluorenone-2-carboxylic acid(784-50-9)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29183000

MSDS

• Language:English Provider:9-Fluorenone-2-carboxylic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

9-Fluorenone-2-carboxylic acid Usage And Synthesis

Chemical Properties

yellow fine powder

Uses

9-Fluorenone-2-carboxylic Acid (cas# 784-50-9) is a compound useful in organic synthesis.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 3958, 1948 DOI: 10.1021/ja01191a530
Organic Syntheses, Coll. Vol. 3, p. 420, 1955

Synthesis

General procedure for the synthesis of 9-fluorenone-2-carboxylic acid from the compound (CAS: 3096-44-4): potassium hydroxide (1.6 g, 29.4 mmol) was added to a mixture of methanol (7 mL) and water (7 mL) containing compound 12 (200 mg, 0.98 mmol), and the reaction mixture was stirred for 6 hours at 110 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The pH was adjusted to 3 with 1 N hydrochloric acid and the mixture was extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford the target product 9-fluorenone-2-carboxylic acid (200 mg, 91% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δ 13.30 (s, 1H), 8.19 (d, J = 7.6 Hz, 1H), 8.03 (s, 1H), 7.97-9.89 ( m, 2H), 7.72-7.64 (m, 2H), 7.50-7.44 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5861 - 5872
[2] Patent: CN104557862, 2017, B. Location in patent: Paragraph 0102-0104; 0109-0110

9-Fluorenone-2-carboxylic acid(784-50-9)Related Product Information

• Glycine
• Ethyl 2-(Chlorosulfonyl)acetate
• Folic acid
• 9-Fluorenone
• Phenylfluorone
• 2,5-Dimethylbenzaldehyde
• 4-Phenyltoluene
• 3'-Methylacetophenone
• 3-Methylbenzophenone
• 3-Methylbenzyl alcohol
• 2-FLUORENECARBOXALDEHYDE
• 3,4-Dimethylbenzaldehyde
• Benzophenone
• 3-Ethylbenzaldehyde
• 2',5'-DIMETHYLACETOPHENONE
• 3,4-Dimethylbenzoic acid
• 9-FLUORENONE-2,7-DICARBOXYLIC ACID
• toluic acid