N-Methylolchloroacetamide Chemical Properties

Melting point:

100-105 °C(lit.)

Boiling point:

374.0±27.0 °C(Predicted)

Density 

1.2776 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

12.63±0.46(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Very soluble in water. Poorly soluble in aliphatic hydrocarbons.

Sensitive 

Hygroscopic

BRN 

1811765

CAS DataBase Reference

2832-19-1(CAS DataBase Reference)

EPA Substance Registry System

2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

Safety Information

Hazard Codes 

C

Risk Statements 

34-43-40-20/21/22

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

RTECS 

AB5733000

TSCA 

Yes

HazardClass 

8

PackingGroup 

Ⅱ

HS Code 

29241990

MSDS

• Language:English Provider:2-Chloro-N-(hydroxymethyl)acetamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Methylolchloroacetamide Usage And Synthesis

Chemical Properties

White or almost white crystalline powder

Uses

N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.

Uses

An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .

Uses

2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).

General Description

2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.

N-Methylolchloroacetamide (2832-19-1)Related Product Information

• DIACETAMIDE
• N-(HYDROXYMETHYL)ACETAMIDE
• Thioacetamide
• Epichlorohydrin
• Dichloroacetamide
• 2-Hydroxyethyl methacrylate
• Acetamide
• Acetaminophen
• Trimethylolpropane
• Tris(hydroxymethyl)nitromethane
• N,N-Dimethylacetamide
• Tris(hydroxymethyl)aminomethane
• 2,2,2-Trichloroacetamide
• methylol cellulose
• Chloroacetamide
• Alachlor
• Machette
• Chloroacetic acid