4,7-Dichloroquinoline Chemical Properties

Melting point:

81-83 °C (lit.)

Boiling point:

298.4 °F (148°C)

Density 

1.4178 (rough estimate)

vapor pressure 

0.103Pa at 25℃

refractive index 

1.6300 (estimate)

Flash point:

164 °C

storage temp. 

2-30°C

solubility 

chloroform: soluble50mg/mL, clear, colorless to greenish-yellow

pka

1.99±0.27(Predicted)

form 

Powder

color 

White to pale brown

Water Solubility 

insoluble

BRN 

125359

InChIKey

HXEWMTXDBOQQKO-UHFFFAOYSA-N

LogP

3.193 at 25℃

CAS DataBase Reference

86-98-6(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 4,7-dichloro-(86-98-6)

EPA Substance Registry System

4,7-Dichloroquinoline (86-98-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-22

WGK Germany 

3

RTECS 

VB4200000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29334910

MSDS

• Language:English Provider:4,7-Dichloroquinoline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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4,7-Dichloroquinoline Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti -microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.

Uses

4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.

General Description

Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Flammability and Explosibility

Not classified

Synthesis

4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.

Purification Methods

Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]

4,7-Dichloroquinoline(86-98-6)Related Product Information

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