2-Chloro-1,3,2-dioxaphospholane Chemical Properties

Melting point:

-28°C(lit.)

Boiling point:

62 °C/20 mmHg (lit.)

Density 

1.422 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.489(lit.)

Flash point:

158 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly)

form 

clear liquid

color 

Colorless to Light yellow

Sensitive 

Moisture Sensitive

BRN 

506179

Stability:

Extremely Moisture Sensitive

CAS DataBase Reference

822-39-9(CAS DataBase Reference)

NIST Chemistry Reference

Ethylene chlorophosphite(822-39-9)

EPA Substance Registry System

1,3,2-Dioxaphospholane, 2-chloro- (822-39-9)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34-37

Safety Statements 

26-36/37/39-45-8-25

RIDADR 

UN 3264 8/PG 2

WGK Germany 

3

F 

1-10

Hazard Note 

Highly reactive cyclic phosphitylating reagent which

TSCA 

Yes

HS Code 

2934.99.9001

HazardClass 

8

PackingGroup 

II

MSDS

• Language:English Provider:Ethylene glycol chlorophosphite
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chloro-1,3,2-dioxaphospholane Usage And Synthesis

Chemical Properties

Clear Colourless Oil

Uses

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

Uses

Ethylene chlorophosphite acts as a phosphitylating agent involved in the preparation of phosphocholine and spirophosphoranes. For example, it is used in the phosphorylation of p-tert-butyl(thia)calixarenes.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

2-Chloro-1,3,2-dioxaphospholane(822-39-9)Related Product Information

• Ethylene glycol
• ETHYLENE OXIDE
• Ethylene carbonate
• Cyclopentyl chloride
• Dimethyl phosphite
• Vinyl acetate
• ETHYLENE DIACRYLATE
• Cyclopentane
• Bromocyclopentane
• Vinylene carbonate
• VINYL CHLORIDE
• 1,2-Dibromoethane
• Methylcyclopentane
• POLY(ETHYLENE)
• Diethylene glycol
• Epichlorohydrin
• ETHYLENE
• Ethylene glycol diacetate