(DL-3-HYDROXY-3-METHYLGLUTARYL) COENZYM& Chemical Properties

storage temp. 

−20°C

solubility 

H₂O: 50 mg/mL, clear, faintly yellow

form 

Solid

color 

White to off-white

Safety Information

WGK Germany 

3

F 

10-21

(DL-3-HYDROXY-3-METHYLGLUTARYL) COENZYM& Usage And Synthesis

Uses

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate has been used in drug treatment to study its effect on mTORC1 regulation. It has also been used to compare the acylomes of two reactive acyl-CoA species, like HMG-CoA and?glutaryl-CoA.

General Description

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)?is obtained from acetyl-CoA?and?acetoacetyl-CoA during condensation with the help of HMG-CoA synthase.

Biochem/physiol Actions

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is a substrate used to study the specificity and kinetics of the enzyme 3-hydroxyl-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase. HMG-CoA is the key intermediate in the biosynthsis of terpenes and ketone bodies. Its metabolism is the target of statin drugs used to control cholesterol levels.