SB 200646 HYDROCHLORIDE
SB 200646 HYDROCHLORIDE Basic information
- Product Name:
- SB 200646 HYDROCHLORIDE
- Synonyms:
-
- SB-200646A
- SB 200646A,SB200646A
- SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist
- 1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
- SB-200646A ，S0893
- CAS:
- 143797-62-0
- MF:
- C15H14N4O.ClH
- MW:
- 302.763
- Mol File:
- 143797-62-0.mol
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SB 200646 HYDROCHLORIDE Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: ~26 mg/mL, soluble
- form
- solid
- color
- pale yellow
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SB 200646 HYDROCHLORIDE Usage And Synthesis
Uses
SB 200646 Hydrochloride is a 5-HT2C antagonist.
in vivo
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |
IC 50
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)
SB 200646 HYDROCHLORIDESupplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
BOC Sciences
- Tel
- info@bocsci.com
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