25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties

storage temp. 

−20°C

solubility 

Soluble in ethanol at 20mg/ml

form 

powder

color 

white

BRN 

7693643

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Usage And Synthesis

Description

ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Uses

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

Definition

ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421

25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(136632-32-1)Related Product Information

• 1 VIAL PROTEASE-INHIBITOR-MIX FY
• PROTEASE INHIBITOR COCKTAIL, W/EDTA
• 1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG)
• TRYPSIN INHIBITOR
• Urinary Trypsin Inhibitor
• DISPASE
• ACHROMOPEPTIDASE
• Trypsin
• MG-115
• trysin-chymotrypsin
• Basic protease
• AC-LEU-VAL-PHE-ALDEHYDE
• Protease Inhibitor Cocktail (For Bacterial Cell, EDTA Free)
• Neutrophil Elastase Inhibitor Screening Kit
• HumanUrinaryTrypsinInhibitor(Uti)
• CALPAIN INHIBITOR I
• Calpain Inhibitor I
• CALPAIN INHIBITOR II