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SULFISOXAZOLE ACETYL (200 MG)

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SULFISOXAZOLE ACETYL (200 MG) Basic information

Product Name:
SULFISOXAZOLE ACETYL (200 MG)
Synonyms:
  • SULFISOXAZOLE ACETYL (200 MG)
  • Acetamide, N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)-
  • Acetyl sulfisoxazole
  • Lipo Gantrisin
  • N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide
  • n-3,4-dimethylisoxazol-5-yl-n-sulfanilylacetamide
  • N-Acetyl-4-amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
  • Sulfisoxazole Acetyl
CAS:
80-74-0
MF:
C13H15N3O4S
MW:
309.3409
EINECS:
2013053
Mol File:
80-74-0.mol
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SULFISOXAZOLE ACETYL (200 MG) Chemical Properties

Melting point:
193-194°
Boiling point:
538.1±60.0 °C(Predicted)
Density 
1.3541 (rough estimate)
refractive index 
1.6320 (estimate)
pka
-0.17±0.10(Predicted)
Water Solubility 
80mg/L(37 ºC)
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Safety Information

HS Code 
2935904000
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SULFISOXAZOLE ACETYL (200 MG) Usage And Synthesis

Originator

Gantrisin Acetyl ,Roche ,US ,1954

Uses

Sulfisoxazole Acetyl is an antibiotic used in the prevention of infection especially when used in conjunction with erythromycin.

Uses

Antibacterial.

Manufacturing Process

267 grams (1 mol) of sulfisoxazole were suspended in 400 ml of acetone and 79 grams (1 mol) of dry pyridine at 20-25°C in a round-bottom flask equipped with a stirrer and thermometer. 132 grams (1 mol) of acetic anhydride were added within 3 minutes with stirring. The sulfisoxazole dissolved in the mixture and a clear solution resulted. The temperature rose to 39-40°C. After stirring for several minutes, the product started to crystallize as a white crystalline mush. The temperature rose to 42-43°C maintained itself at this temperature for 15-30 minutes, and then started to drop. Stirring was continued for 5 hours and the mixture was then allowed to stand for 10 hours. One liter of 2.5-3.0% ice-cold aqueous ammonia and some fresh ice were then added while stirring and the crystals were filtered without delay. The crystals were washed on the filter with 1 liter of ice-cold 1% ammonia and then with 1 liter of water. The material on the filter was well pressed off, washed with 200-300 ml of alcohol and dried at 70°C to constant weight. The N-monoacetyl sulfisoxazole melted at 193-194°C and showed a positive Bratton-Marshall reaction and a positive Hucknall-Turfat reaction.
The product is in the form of colorless crystals which are somewhat water repellent. It is insoluble in alkali but is saponified upon standing in alkaline suspension (3% ammonia). It is soluble in strong acids (20-36% HCl or 10 N H2SO4) and is rapidly saponified upon standing.

brand name

Gantrisin (Roche).

Therapeutic Function

Antimicrobial

General Description

Sulfisoxazole acetyl shares the actions and usesof the parent compound, sulfisoxazole. The acetyl derivativeis tasteless and, therefore, suitable for oral administration, especiallyin liquid preparations. The acetyl compound is splitin the intestinal tract and absorbed as sulfisoxazole; that is, itis a prodrug for sulfisoxazole.

SULFISOXAZOLE ACETYL (200 MG) Preparation Products And Raw materials

Raw materials

SULFISOXAZOLE ACETYL (200 MG)Supplier

Nanjing Chemlin Chemical Co., Ltd
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Sinopharm Chemical Reagent Co,Ltd.
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ShangHai Angti Biotechnology Co., Ltd.
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13764913901
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-40096860 4009686088
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Amadis Chemical Company Limited
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571-89925085
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