3-BROMO-4-FLUOROBENZYL BROMIDE Chemical Properties

Melting point:

41 °C

Boiling point:

259.8±25.0 °C(Predicted)

Density 

1.923±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

form 

Solid

color 

White

Water Solubility 

Slightly soluble in water.

Sensitive 

Lachrymatory

Safety Information

Hazard Codes 

C,T

RIDADR 

3261

HazardClass 

8

PackingGroup 

II

HS Code 

2903998090

3-BROMO-4-FLUOROBENZYL BROMIDE Usage And Synthesis

Uses

3-Bromo-4-fluorobenzyl bromide is used as a pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 3-bromo-4-fluorobenzyl bromide from 3-bromo-4-fluorotoluene: 3-bromo-4-fluorotoluene (6 mL, 48 mmol) and N-bromosuccinimide (2.7 g, 15 mmol) were dissolved in 1,2-dichloroethane, followed by the addition of 2,2'-azobisisobutyronitrile (16 mg, 0.1 mmol) to a 1,2-dichloroethane solution ( 10 mL). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, diluted with 1,2-dichloroethane (40 mL) and washed with water (2 x 50 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated to a small volume under reduced pressure. The product 3-bromo-4-fluorobenzyl bromide was obtained (yield: 9.2 g, 72% yield).

References

[1] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 71
[2] Journal of medicinal chemistry, 1967, vol. 10, # 1, p. 64 - 66
[3] Patent: US6586633, 2003, B1

3-BROMO-4-FLUOROBENZYL BROMIDE(78239-71-1)Related Product Information

• 3-Fluoro-5-bromobenzyl bromide
• 2-Bromo-1-(bromomethyl)-4-fluorobenzene
• 2-Bromo-5-fluorobenzyl bromide
• 2-Chloro-4-fluorobenzyl bromide
• 2-Fluoro-6-bromobenzyl bromide
• 2-Fluoro-5-bromobenzyl bromide
• 2-Fluoro-4-chlorobenzyl bromide
• 3-CHLORO-4-FLUOROBENZYL BROMIDE
• 2-Chloro-5-fluorobenzyl bromide
• 3-Fluoro-4-bromobenzyl bromide
• 4-Bromo-2-fluorobenzyl bromide
• 2-Bromo-1-(bromomethyl)-3-fluorobenzene