Vipivotide tetraxetan Linker Chemical Properties

Boiling point:

1063.2±65.0 °C(Predicted)

Density 

1.303±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. -20°C

pka

3.78±0.10(Predicted)

form 

Solid

color 

White to off-white

InChIKey

JHWCOTSIOATVKA-UIGMUVSQSA-N

SMILES

C(O)(=O)[C@H](CCCCNC(=O)[C@H](CC1=CC=C2C(=C1)C=CC=C2)NC([C@@H]1CC[C@@H](CN)CC1)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O

Vipivotide tetraxetan Linker Usage And Synthesis

Uses

Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA)[1].

IC 50

Non-cleavable Linker

References

[1] Bene?ová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946. DOI:10.1021/acs.molpharmaceut.7b00877

Vipivotide tetraxetan Linker(1703768-74-4)Related Product Information

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