Thalidomide-O-amido-C4-NH2 hydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

color 

White to off-white

Safety Information

HS Code 

2933998090

Thalidomide-O-amido-C4-NH2 hydrochloride Usage And Synthesis

Uses

Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Thalidomide-O-amido-C4-NH2 hydrochloride(2245697-86-1)Related Product Information

• N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
• Thalidomide-O-C6-NH2
• Thalidomide-O-C6-NH2 TFA
• Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
• Thalidomide-O-amido-C3-NH2 (TFA)
• 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
• Cereblon Ligand 1
• E3 Ligase Ligand-Linker Conjugates 21
• E3 Ligase Ligand-Linker Conjugates 19
• Thalidomide-O-PEG4-Propargyl
• Thalidomide-linker 10
• Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
• Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
• Thalidomide-O-amido-C8-NH2 hydrochloride
• Thalidomide-O-PEG4-Boc
• tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate
• Thalidomide-linker 13
• E3 Ligase Ligand-Linker Conjugates 24 (TFA)