Thalidomide-NH-C4-NH2 TFA
Thalidomide-NH-C4-NH2 TFA Basic information
- Product Name:
- Thalidomide-NH-C4-NH2 TFA
- Synonyms:
-
- Thalidomide-NH-C4-NH2 TFA
- Pomalidomide Related Compound 10 Triflate
- 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate
- halidomide-NH-C4-NH2TFA
- Pomalidomide-C4-NH2 TFA
- Poma-C4-NH2 TFA
- CAS:
- 2093387-50-7
- MF:
- C19H21F3N4O6
- MW:
- 458.39
- Mol File:
- 2093387-50-7.mol
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Thalidomide-NH-C4-NH2 TFA Usage And Synthesis
Biological Activity
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
References
[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.
Thalidomide-NH-C4-NH2 TFASupplier
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