Thalidomide-4-O-C8-NH2
Thalidomide-4-O-C8-NH2 Basic information
- Product Name:
- Thalidomide-4-O-C8-NH2
- Synonyms:
-
- 4-((8-Aminooctyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- Thalidomide-O-C8-NH2
- 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
- Thalidomide-4-O-C8-NH2
- 4-[(8-Aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- 4-[(8-aminooctyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
- CAS:
- 1957235-91-4
- MF:
- C21H27N3O5
- MW:
- 401.46
- Mol File:
- 1957235-91-4.mol
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Thalidomide-4-O-C8-NH2 Chemical Properties
- Boiling point:
- 639.9±55.0 °C(Predicted)
- Density
- 1.274±0.06 g/cm3(Predicted)
- pka
- 10.70±0.40(Predicted)
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Thalidomide-4-O-C8-NH2 Usage And Synthesis
Uses
Thalidomide-4-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50
Cereblon
References
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024
Thalidomide-4-O-C8-NH2 Supplier
Daicel Chiral Technologies (China)CO.,LTD
- Tel
- 021-50460086-9 15921403865
- han_yajun@dctc.daicel.com
Jilin Province Woda Biotechnology Co., Ltd.
- Tel
- 13504435624
- 1927928688@qq.com
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
- Tel
- 025-86755008 17751752005
- hszhang@bestfluorodrug.com
ShenZhen Trendseen Biological Technology Co.,Ltd.
- Tel
- 13417589054;
- trendseenbio@gmail.com
Shanghai Easy CDMO Co.,Ltd
- Tel
- 021-61734564 13854185395;
- info@easycdmo.com
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Thalidomide-4-O-C8-NH2 (1957235-91-4)Related Product Information
- Thalidomide-O-C6-NH2
- Thalidomide-O-C6-NH2 TFA
- Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- Thalidomide-O-C5-NH2
- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- Thalidomide-O-PEG4-amine
- Thalidomide-O-PEG4-NHS ester
- 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- Thalidomide-O-PEG3-amine HCl
- Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- Thalidomide-O-PEG4-azide
- Thalidomide-O-C3-acid
- Thalidomide-O-C5-acid
- Thalidomide-NH-PEG2-C2-NH2 (TFA)
- 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,
- Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-
- 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-
- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,