LCKLSL Chemical Properties

Boiling point:

1024.2±65.0 °C(Predicted)

Density 

1.185±0.06 g/cm3(Predicted)

pka

3.30±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Leu-Cys-Lys-Leu-Ser-Leu

LCKLSL Usage And Synthesis

Uses

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

in vivo

References

[1] Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64. DOI:10.1242/jcs.079236

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