A-3 HYDROCHLORIDE Chemical Properties

Melting point:

173-176°C

storage temp. 

-20°C

solubility 

DMSO: 24 mg/mL

form 

solid

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2935909099

MSDS

• Language:English Provider:SigmaAldrich

A-3 HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Inhibits cAMP and cGMP dependent protein kinases. Also inhibits MLC kinase and protein kinase C

Biochem/physiol Actions

Non-selective casein kinase (CK) inhibitor. A shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki = 80 μM), casein kinase II (Ki = 5.1 μM), myosin light chain kinase (Ki = 7.4 μM), protein kinase A (Ki = 4.3 μM), protein kinase C (Ki= 47 μM), and protein kinase G (Ki = 3.8 μM).

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