L-(-)-Histidinol dihydrochloride Chemical Properties

Melting point:

198-201 °C (dec.)(lit.)

alpha 

-3 º (C=2, H2O 24 ºC)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Sparingly)

form 

Crystalline Powder

color 

White to slightly beige

BRN 

3914853

InChIKey

FRCAFNBBXRWXQA-XRIGFGBMSA-N

CAS DataBase Reference

1596-64-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39-36/37-22

WGK Germany 

3

RTECS 

NI8260000

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

L-(-)-Histidinol dihydrochloride Usage And Synthesis

Description

L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.

Chemical Properties

white to slightly beige crystalline powder

Uses

A metabolite within Histidine metabolism.

Definition

ChEBI: L-Histidinol dihydrochloride is an aralkylamine.

in vitro

preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].

in vivo

l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].

References

[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.

L-(-)-Histidinol dihydrochloride(1596-64-1)Related Product Information

• Tris(hydroxymethyl)aminomethane
• 6-Aminocaproic acid
• ALTRENOGEST
• 1-Propanol
• Glycine
• Ketorolac tromethamine
• Fosfomycin tromethamine
• TRISTEARIN
• Glycinamide hydrochloride
• Imidazole
• Dihydrochloride
• N'-Methyl-L-histidine methyl ester
• L-HISTIDINE DIHYDROCHLORIDE
• Methyl L-histidinate dihydrochloride
• (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride
• H-HIS(BZL)-OME 2 HCL
• D(+)-HISTIDINOL DIHYDROCHLORIDE
• L-Histidine