2,4-Thiazolidinedione Chemical Properties

Melting point:

125-127 °C (lit.)

Boiling point:

178-179 °C (19 mmHg)

Density 

1.408 (estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5130 (estimate)

Flash point:

178-179°C/19mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

6.50±0.10(Predicted)

color 

Slightly yellow

Water Solubility 

Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.

BRN 

110700

InChIKey

ZOBPZXTWZATXDG-UHFFFAOYSA-N

LogP

-0.29 at 25℃

CAS DataBase Reference

2295-31-0(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Thiazolidinedione(2295-31-0)

EPA Substance Registry System

2,4-Thiazolidinedione (2295-31-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

RTECS 

XJ5775000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29341000

MSDS

• Language:English Provider:Thiazolidine-2,4-dione
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Thiazolidinedione Usage And Synthesis

Chemical Properties

White to Off-White Powder

Uses

Inhibitor of enzyme

Uses

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

Definition

ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.

General Description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Flammability and Explosibility

Not classified

2,4-Thiazolidinedione(2295-31-0)Related Product Information

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