Thioflavine T Chemical Properties

Melting point:

211-212 °C (decomp)

Density 

1.301g/cm3 at 20℃

vapor pressure 

0Pa at 25℃

storage temp. 

Store below +30°C.

solubility 

methanol: soluble1mg/mL

Colour Index 

49005

form 

Powder

color 

Yellow to ochre-yellow

BRN 

3922452

LogP

3.02 at 25℃ and pH7.98

CAS DataBase Reference

2390-54-7(CAS DataBase Reference)

EPA Substance Registry System

Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (2390-54-7)

Safety Information

Safety Statements 

24/25

RIDADR 

2811

WGK Germany 

3

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

32041300

MSDS

• Language:English Provider:Basic Yellow 1
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Thioflavine T Usage And Synthesis

Chemical Properties

yellow to ochre-yellow powder

Uses

Textile dyeing, fluorescent sign paints, in combination with green or blue pigments to produce brilliant greens, phosphotungstic pigments.

Uses

A dye used to visualize beta-amyloid plaques, like those associated with Alzheimer's Disease

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Preparation

4-(6-Methyl-2,3-dihydrobenzo[d]thiazol-2-yl)benzenamine?with methanol and hydrochloric acid or sulfuric acid, at 160 ~ 170 ℃ methylation under pressure.

General Description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

Properties and Applications

colourful green light yellow. Soluble in cold water, soluble in hot water for yellow, easily soluble in ethanol and yellow, with green fluorescent. The strong sulfuric acid to colorless, a green fluorescent, diluted into light yellow.

Standard( Silk )	Light Fastness	Persperation Fastness		Ironing Fastness		Soaping
		Fading	Stain	Fading	Stain	Fading	Stain
C	3	2-3		4		1

Purification Methods

Crystallise the chloride from *benzene/EtOH (1:1). [Beilstein 27 III/IV 5052.]

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