Tobramycin sulfate Chemical Properties

storage temp. 

2-8°C

form 

Liquid

Water Solubility 

Soluble in water (50 mg/ml).

InChIKey

ZEUUPKVZFKBXPW-UHFFFAOYSA-N

SMILES

O1C(CO)C(O)C(N)C(O)C1OC1C(N)CC(N)C(OC2C(N)CC(O)C(CN)O2)C1O.S(O)(O)(=O)=O

CAS DataBase Reference

79645-27-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

61-20/21/22

Safety Statements 

53-22-36/37/39-45-3/7/9

WGK Germany 

3

RTECS 

WK2110000

MSDS

• Language:English Provider:SigmaAldrich

Tobramycin sulfate Usage And Synthesis

Description

Tobramycin Sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis.

Originator

Nebcin (Lilly).

Uses

Tobramycin Sulfate is an antibiofilm formulations.

Indications

Used in the treatment of septicemia (bloodstream infection), infections of the skin, bone, lower respiratory tract, central nervous system, intra-abdominal and complicated recurrent urinary tract infections.

Side effects

The most common side effects of Tobramycin sulfate include:

• Nephrotoxicity (Kidney Toxicity)

Tobramycin sulfate, like other aminoglycosides, can cause nephrotoxicity. This toxicity is usually reversible discontin uponuation of the drug. It is more likely to occur with prolonged use or in patients with pre-existing kidney dysfunction.

• Ototoxicity (Ear Toxicity)

Ototoxicity is another common side effect, which can manifest as vestibular dysfunction or hearing loss. This toxicity is often irreversible and may be more prevalent in patients with genetic predispositions.

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